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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-4-13
|
| pubmed:abstractText |
The gene for the alpha isoform of the catalytic subunit of human protein phosphatase 2A (PPP2CA) was localized to chromosome 5 using somatic cell hybrids, and then more finely mapped to chromosome region 5q23-->q31 by in situ hybridization using a tritiated cDNA probe. The gene for the beta isoform of the catalytic subunit of this enzyme (PPP2CB) was mapped by the polymerase chain reaction to human chromosome 8 using somatic cell hybrids. Fluorescence in situ hybridization was then used to localize the PPP2CB gene to 8p12-->p11.2, using a mixture of three genomic probes that ranged from 3.5 to 8 kb in size. Finally, Southern blot analysis of somatic cell hybrid DNA suggested that a PPP2CB catalytic subunit pseudogene (PPP2CBP) is on chromosome 16.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0301-0171
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
63
|
| pubmed:geneSymbol |
PPP2CA,
PPP2CB,
PPP2CBP
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
35-41
|
| pubmed:dateRevised |
2009-4-27
|
| pubmed:meshHeading |
pubmed-meshheading:8383590-Animals,
pubmed-meshheading:8383590-Autoradiography,
pubmed-meshheading:8383590-Base Sequence,
pubmed-meshheading:8383590-Blotting, Southern,
pubmed-meshheading:8383590-Cell Line,
pubmed-meshheading:8383590-Chromosome Mapping,
pubmed-meshheading:8383590-Chromosomes, Human, Pair 16,
pubmed-meshheading:8383590-Chromosomes, Human, Pair 5,
pubmed-meshheading:8383590-Chromosomes, Human, Pair 8,
pubmed-meshheading:8383590-Cricetinae,
pubmed-meshheading:8383590-DNA,
pubmed-meshheading:8383590-Humans,
pubmed-meshheading:8383590-Hybrid Cells,
pubmed-meshheading:8383590-In Situ Hybridization,
pubmed-meshheading:8383590-Mice,
pubmed-meshheading:8383590-Molecular Sequence Data,
pubmed-meshheading:8383590-Phosphoprotein Phosphatases,
pubmed-meshheading:8383590-Polymerase Chain Reaction,
pubmed-meshheading:8383590-Protein Phosphatase 2,
pubmed-meshheading:8383590-Rats
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Localization of the genes encoding the catalytic subunits of protein phosphatase 2A to human chromosome bands 5q23-->q31 and 8p12-->p11.2, respectively.
|
| pubmed:affiliation |
Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|