Linked Life Data

8383094

Source:http://linkedlifedata.com/resource/pubmed/id/8383094

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-4-5
pubmed:databankReference
pubmed:abstractText
cDNA clones, representing transcripts expressed in human fetal brain, have been isolated that specify the 5' end of the adenomatous polyposis coli (APC) gene. Sequence analyses have revealed an alternative 5' untranslated region (5'UTR) of the APC gene; this region is comprised of at least 103 basepairs. A comparison of this alternative UTR with the published sequence of the APC-gene indicates that these two 5'UTR sequences diverge beyond nucleotide position -20 with respect to the A of the authentic translational initiation codon. These data suggest that two APC-specific promoter elements exist, giving rise to two different untranslated regions. Within the alternative UTR, we have identified 3 additional AUG codons, located 5' to the intrinsic APC initiation site. Two of these AUG codons are located in a nucleotide context that favours initiation of truncated translation products. The relevance of these additional AUG codons to a regulatory mechanism acting at the post-transcriptional level of APC gene expression is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0340-6717
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:geneSymbol
APC
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
650-2
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Identification of an alternative 5' untranslated region of the adenomatous polyposis coli gene.
pubmed:affiliation
Institut für Humangenetik der Universität, Erlangen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't