rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1-2
|
pubmed:dateCreated |
1993-3-31
|
pubmed:databankReference |
|
pubmed:abstractText |
Human cytochrome c oxidase (COX) is a complex of 13 subunits: three are encoded by mitochondrial DNA and ten by nuclear DNA. We have now isolated a full-length cDNA specifying subunit VIIb, the last remaining uncharacterized nuclear-encoded subunit cDNA of human COX. The cDNA encodes a deduced 80-aa polypeptide, including a 24-amino acid (aa) N-terminal leader sequence and a 56-aa mature polypeptide with 82% identity to mature bovine COX VIIb. Southern blot hybridization of human muscle genomic DNA showed multiple hybridizing bands, implying the presence of a large coxVIIb gene family, including a potential processed pseudogene.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0006-3002
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
20
|
pubmed:volume |
1172
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
223-5
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:8382530-Amino Acid Sequence,
pubmed-meshheading:8382530-Base Sequence,
pubmed-meshheading:8382530-DNA, Mitochondrial,
pubmed-meshheading:8382530-Electron Transport Complex IV,
pubmed-meshheading:8382530-Humans,
pubmed-meshheading:8382530-Macromolecular Substances,
pubmed-meshheading:8382530-Molecular Sequence Data,
pubmed-meshheading:8382530-RNA, Messenger,
pubmed-meshheading:8382530-Restriction Mapping,
pubmed-meshheading:8382530-Sequence Homology, Nucleic Acid
|
pubmed:year |
1993
|
pubmed:articleTitle |
Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase.
|
pubmed:affiliation |
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|