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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-3-23
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pubmed:abstractText |
Two transgenic rabbits (TRI and TRIII) that carried cottontail rabbit papillomavirus (CRPV) DNA alone were identified; another (TRII) carried both CRPV DNA and EJ-ras. TRI and TRIII developed extensive skin papillomas at about 1 month of age, and transcripts of CRPV DNA were detectable only in skin and/or papillomas. TRII developed extensive squamous carcinomas of the skin at a very early age. Transcription of both CRPV DNA and EJ-ras was found in the skin cancers. Thus, the tissue specificity of CRPV DNA expression in transgenic rabbits was the same as in virion-infected animals. The expression of EJ-ras could be dependent on the expression of certain CRPV genes and may be a critical cofactor of CRPV DNA in the progression of carcinomas.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-1366359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-1692766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-1851881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-2434663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-2456144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-2541388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-2557758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-2834733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-2838778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-2855020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-2983228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-3011085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-3018579,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-3039808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-5061309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-6093372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-6280459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-6289064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-6292489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-6308472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-6462235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8382316-6877385
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1698-701
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8382316-Animals,
pubmed-meshheading:8382316-Animals, Genetically Modified,
pubmed-meshheading:8382316-Carcinoma,
pubmed-meshheading:8382316-Cottontail rabbit papillomavirus,
pubmed-meshheading:8382316-DNA, Neoplasm,
pubmed-meshheading:8382316-Genes, Viral,
pubmed-meshheading:8382316-Genes, ras,
pubmed-meshheading:8382316-Papilloma,
pubmed-meshheading:8382316-Rabbits,
pubmed-meshheading:8382316-Skin,
pubmed-meshheading:8382316-Tissue Distribution,
pubmed-meshheading:8382316-Transcription, Genetic
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pubmed:year |
1993
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pubmed:articleTitle |
Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA.
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pubmed:affiliation |
Department of Comparative Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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