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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-3-18
|
| pubmed:abstractText |
A factory in France had used technical-grade chloromethyl-methyl-ether in the manufacture of anion exchange resins since 1958. Technical-grade chloromethyl-methyl-ether contains a human lung carcinogen, bis-chloromethyl-ether. The purpose of this cohort study was to determine if workers at the factory whose jobs had involved potential exposure to technical chloromethyl-methyl-ether had a higher incidence of lung cancer than coworkers, or others without potential exposure. Lung cancer occurred at a higher rate among potentially exposed workers than among nonexposed workers at the same plant (rate ratio (RR) = 5.0, 95% confidence interval (CI) 2.0-12.3), or among an external reference population (RR = 7.6, 95% CI 4.3-13.5). The average age at diagnosis for exposed cases was 10.5 years lower than for nonexposed cases. The predominantly small-cell cancers of the exposed were mostly oat-cell. There was a positive dose-response relation. The mean time from first exposure to diagnosis was 13 years (95% CI 8-18). Cumulative dose and induction time were not associated. The rate for the exposed workers peaked between 7 and 13 years after the start-up of the chloromethylation process, and was still above background in 1986, the end of the study period.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0002-9262
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
137
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
31-42
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8382005-Bis(Chloromethyl) Ether,
pubmed-meshheading:8382005-Carcinoma, Small Cell,
pubmed-meshheading:8382005-Dose-Response Relationship, Drug,
pubmed-meshheading:8382005-France,
pubmed-meshheading:8382005-Humans,
pubmed-meshheading:8382005-Incidence,
pubmed-meshheading:8382005-Least-Squares Analysis,
pubmed-meshheading:8382005-Lung Neoplasms,
pubmed-meshheading:8382005-Male,
pubmed-meshheading:8382005-Middle Aged,
pubmed-meshheading:8382005-Occupational Diseases,
pubmed-meshheading:8382005-Occupational Exposure,
pubmed-meshheading:8382005-Time Factors
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Incidence of respiratory cancer among workers exposed to chloromethyl-ethers.
|
| pubmed:affiliation |
Epidemiology Department, Rohm and Haas Co., Bristol, PA 19007.
|
| pubmed:publicationType |
Journal Article
|