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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-3-16
|
| pubmed:abstractText |
1. Whole-cell recordings were performed on acutely isolated pyramidal neurons from rat sensorimotor cortex 2 to 21 days postnatal to study the expression of a tetrodotoxin (TTX) sensitive, voltage dependent, persistent Na+ current (INaP) during different stages of postnatal development. 2. INaP was activated positive to about -60 mV and attained its peak amplitude between -40 and -35 mV. Activation of INaP did not require preceding activation of the transient Na+ current. 3. Peak INaP amplitudes showed a three-fold increase over the first three postnatal weeks, starting from 60.7 +/- 7.5 (SE) pA (n = 6) at postnatal day (P) 2-P5 and reaching 189.1 +/- 20.4 pA (n = 13) at P17-P21. 4. Measurements of peak INaP density, which took concomitant cell growth into account, revealed that a considerable current density already existed in very young neurons (P2-P5: 4.3 +/- 1.0 microA/cm2, n = 6) when compared with INaP density in early adult neurons (P17 - P21: 8.9 +/- 0.8 microA/cm2, n = 5). 5. Our data provide the first direct evidence for the presence of a significant INaP density during early postnatal development of neocortical neurons indicating that this current should play a role in the control of intrinsic excitability at this age.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-3077
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
69
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
290-2
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8381860-Animals,
pubmed-meshheading:8381860-Animals, Newborn,
pubmed-meshheading:8381860-Cell Differentiation,
pubmed-meshheading:8381860-Membrane Potentials,
pubmed-meshheading:8381860-Neurons,
pubmed-meshheading:8381860-Rats,
pubmed-meshheading:8381860-Sodium,
pubmed-meshheading:8381860-Sodium Channels,
pubmed-meshheading:8381860-Somatosensory Cortex,
pubmed-meshheading:8381860-Synaptic Transmission
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Postnatal development of a persistent Na+ current in pyramidal neurons from rat sensorimotor cortex.
|
| pubmed:affiliation |
Department of Physiology and Biophysics, School of Medicine, University of Washington, Seattle 98195.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|