Linked Life Data

8381711

Source:http://linkedlifedata.com/resource/pubmed/id/8381711

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-3-18
pubmed:abstractText
Based on the hypothesis that three main cytogenetic subtypes of salivary gland pleomorphic adenomas can be distinguished which may also represent different etiologic entities, we investigated whether these subtypes correspond to clinical, histologic, or biologic features of 220 tumors karyotyped (including 117 tumors with detailed clinical history and histologic subtyping). The following results were obtained. As compared with the group of patients showing salivary gland pleomorphic adenomas with an apparently normal karyotype, the patients in the "8q12-group" were significantly younger (51.1 years versus 39.3 years, p < 0.001). The distribution of histologic subtypes also showed highly significant differences between the groups. Whereas the breakpoint in the 8q12 group was always mapped to a single band, no exact localization of the breakpoint in the group of tumors showing chromosome number 12 abnormalities was possible. In most cases, however, the breakpoints were clustered to 12q15. Finally, all tumors with 8q12 breakpoints showed a characteristic in vitro cellular morphology which was also observed in a few tumors with an apparently normal karyotype but in none of the tumors with the 12q13-15 breakpoint.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-31
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Cytogenetic subtyping of 220 salivary gland pleomorphic adenomas: correlation to occurrence, histological subtype, and in vitro cellular behavior.
pubmed:affiliation
Centre of Human Genetics and Genetic Counselling, University of Bremen, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't