Linked Life Data

8381273

Source:http://linkedlifedata.com/resource/pubmed/id/8381273

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-3-3
pubmed:abstractText
We studied non-mitogenic signal transduction in a human cell line of epidermal origin which is induced to chemotaxis following stimulation with human urokinase-type plasminogen activator (u-PA) or with the amino-terminal fragment (ATF) of u-PA A chain, which specifically interacts with the cellular receptor. U-PA and ATF stimulated the formation of diacylglycerol (DAG) independently of inositol lipid and phosphatidylcholine turnover, but concomitantly with de novo synthesis from glucose, thus resembling the DAG neosynthesis activated by insulin. DAG was measured in normal epidermal cells and in cells transfected with the human u-PA receptor (u-PAR) gene and stimulated with u-PA or ATF. Transfected clones showed an increase of cell motility under an ATF gradient in vitro as well as an increase of DAG production. These findings identify a novel mechanism of second messenger formation that conveys chemotactic signals upon stimulation of the u-PAR.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
190
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-52
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Urokinase-urokinase receptor interaction: non-mitogenic signal transduction in human epidermal cells.
pubmed:affiliation
Institute of General Pathology, Firenze, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't