Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
18
pubmed:dateCreated
1993-10-20
pubmed:abstractText
Photoreceptors of transgenic mice expressing a mutant rhodopsin gene (Pro347-->Ser) slowly degenerate. The mechanism of degeneration was studied by aggregation of embryos of normal and transgenic mice to form chimeras. In these chimeras, mosaicism was observed in the coat color, retinal pigment epithelium, and retina. In the retina, the genotype of adjacent patches of normal and transgenic photoreceptors was determined by in situ hybridization with a transgene-specific RNA probe. Photoreceptors in the chimeric retina degenerated uniformly, independent of the genotype and similar to the photoreceptors in transgenic mice. However, the chimeric retinas showed varying proportions of normal and transgenic cells. The chimeric retina with a nearly even proportion of normal and transgenic photoreceptors displayed uniform but slower degeneration than that observed in a transgenic mouse of the same age. Our results demonstrate non-autonomy of gene action for the mutated rhodopsin gene and imply that cellular interactions between photoreceptors in the retina probably play a role in degeneration.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-1418997, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-1454803, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-1656438, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-16725947, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-1833777, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-1862076, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-1977087, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-1986774, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-1992463, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-2215617, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-2443792, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-2681088, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-2940114, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-2967911, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-3229129, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-4887011, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-6489472, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-6860611, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-8394174, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-8473105, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-8516292, http://linkedlifedata.com/resource/pubmed/commentcorrection/8378322-976367
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8484-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene.
pubmed:affiliation
Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't