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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1993-10-20
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pubmed:databankReference |
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pubmed:abstractText |
Interleukin 3 (IL-3) regulates the proliferation and differentiation of hematopoietic cells. Although the IL-3 receptor chains lack kinase catalytic domains, IL-3 induces tyrosine phosphorylation of cellular proteins. To investigate the potential role of the JAK family of protein-tyrosine kinases in IL-3 signal transduction, we have obtained full-length cDNA clones for murine Jak1 and Jak2 protein-tyrosine kinases and prepared antiserum against the predicted proteins. Using antisera against Jak2, we demonstrate that IL-3 stimulation results in the rapid and specific tyrosine phosphorylation of Jak2 and activates its in vitro kinase activity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1386289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1496401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1502203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1502204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1567546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1590989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1620548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1630447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1631562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1638019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1638633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1848663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1848670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-1956336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-2216457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-2461935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-2466296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-2469962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-2674853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-2681215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-2842066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-3291115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-3296190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-3313277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-6194425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-6196603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-7678927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-8343951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8378315-8343952
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8429-33
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8378315-Amino Acid Sequence,
pubmed-meshheading:8378315-Animals,
pubmed-meshheading:8378315-Base Sequence,
pubmed-meshheading:8378315-Bone Marrow,
pubmed-meshheading:8378315-Cell Line,
pubmed-meshheading:8378315-Cells, Cultured,
pubmed-meshheading:8378315-Cloning, Molecular,
pubmed-meshheading:8378315-DNA,
pubmed-meshheading:8378315-Interleukin-3,
pubmed-meshheading:8378315-Janus Kinase 2,
pubmed-meshheading:8378315-Mice,
pubmed-meshheading:8378315-Molecular Sequence Data,
pubmed-meshheading:8378315-Monocytes,
pubmed-meshheading:8378315-Oligodeoxyribonucleotides,
pubmed-meshheading:8378315-Polymerase Chain Reaction,
pubmed-meshheading:8378315-Protein Biosynthesis,
pubmed-meshheading:8378315-Protein-Tyrosine Kinases,
pubmed-meshheading:8378315-Proto-Oncogene Proteins,
pubmed-meshheading:8378315-RNA, Messenger,
pubmed-meshheading:8378315-Signal Transduction,
pubmed-meshheading:8378315-Transcription, Genetic
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pubmed:year |
1993
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pubmed:articleTitle |
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.
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pubmed:affiliation |
Department of Biochemistry, St. Jude Children's Research Hospital, Memphis, TN 38105.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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