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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-10-18
|
| pubmed:abstractText |
A sensitive method for the determination of nicorandil, an anti-anginal drug, has been developed. The method involves solid-phase extraction of the drug and an internal standard using a Bond-Elut PH extraction column, liquid-liquid extraction with methyl acetate and dichloromethane, and reversed-phase high-performance liquid chromatography on a mu Bondapak C18 column with an ultraviolet detector. The limit of determination in plasma was 3 ng/ml and the intra-day coefficient of variation (n = 7) was less than 10%.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0021-9673
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
23
|
| pubmed:volume |
617
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
163-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8376532-Anti-Arrhythmia Agents,
pubmed-meshheading:8376532-Chromatography, High Pressure Liquid,
pubmed-meshheading:8376532-Humans,
pubmed-meshheading:8376532-Molecular Structure,
pubmed-meshheading:8376532-Niacinamide,
pubmed-meshheading:8376532-Nicorandil,
pubmed-meshheading:8376532-Reproducibility of Results,
pubmed-meshheading:8376532-Spectrophotometry, Ultraviolet,
pubmed-meshheading:8376532-Vasodilator Agents
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Sensitive method for determination of nicorandil in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.
|
| pubmed:affiliation |
Assay Technology Laboratory, Development and Technology Division, Chugai Phamaceutical Co. Ltd., Tokyo, Japan.
|
| pubmed:publicationType |
Journal Article
|