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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
27
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pubmed:dateCreated |
1993-10-20
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pubmed:abstractText |
The role of apolipoprotein A-II (apoA-II) in the metabolism of high density lipoproteins (HDL) is poorly understood. Previous studies of naturally occurring variations of apoA-II in mice have, however, suggested that apoA-II expression influences HDL size and concentration. We now provide definitive evidence of this using transgenic mice overexpressing mouse apoA-II. Thus, as compared with nontransgenic littermates, transgenic mice possessing 4-fold elevations of apoA-II mRNA and 2-3-fold elevations in plasma apoA-II levels exhibited more than a 2-fold increase in HDL levels as well as about a 25% increase in average HDL diameter. Overexpression of mouse apoA-II also resulted in a substantial decrease in the levels of apolipoprotein E associated with HDL, suggesting that apoA-II can displace apoE from HDL. The apoA-II transgenic mice also exhibited a 2-4-fold increase in plasma very low density and low density lipoprotein-cholesterol levels, suggesting novel interactions among the classes of plasma lipoproteins.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
268
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
20676-82
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8376417-Animals,
pubmed-meshheading:8376417-Antibodies, Monoclonal,
pubmed-meshheading:8376417-Apolipoprotein A-I,
pubmed-meshheading:8376417-Apolipoprotein A-II,
pubmed-meshheading:8376417-Apolipoproteins,
pubmed-meshheading:8376417-Chromatography, Gel,
pubmed-meshheading:8376417-Cloning, Molecular,
pubmed-meshheading:8376417-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8376417-Female,
pubmed-meshheading:8376417-Gene Expression,
pubmed-meshheading:8376417-Intestines,
pubmed-meshheading:8376417-Kidney,
pubmed-meshheading:8376417-Lipoproteins,
pubmed-meshheading:8376417-Liver,
pubmed-meshheading:8376417-Male,
pubmed-meshheading:8376417-Mice,
pubmed-meshheading:8376417-Mice, Transgenic,
pubmed-meshheading:8376417-Organ Specificity,
pubmed-meshheading:8376417-RNA, Messenger,
pubmed-meshheading:8376417-Restriction Mapping,
pubmed-meshheading:8376417-Sex Factors
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pubmed:year |
1993
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pubmed:articleTitle |
Influence of mouse apolipoprotein A-II on plasma lipoproteins in transgenic mice.
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pubmed:affiliation |
Department of Medicine, University of California, Los Angeles 90024.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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