Linked Life Data

8375624

Source:http://linkedlifedata.com/resource/pubmed/id/8375624

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-10-21
pubmed:abstractText
This study was undertaken to investigate the effect of epidermal growth factor (EGF) on the rat small intestinal mucosa by three different routes of administration. Four-week-old rats were fed elemental diet for 4 weeks and were administered EGF either subcutaneously, intraluminally or intraperitoneally with mini-osmotic pumps for a week. Intraperitoneal administration of EGF resulted in a significant increase of mucosal wet weight, mucosal content of protein and DNA, villus height, crypt depth and crypt cell production rate. Intraluminal or subcutaneous administration of EGF tended to increase those morphological and proliferative parameters, but did not cause any significant change. We conclude that EGF caused the hyperplasia of the small intestine of rats maintained on oral elemental diet and that this trophic effect was clearly shown by the intraperitoneal route of administration, rather than by the intraluminal route. These results suggest that EGF receptors located in the basal portion of crypt cells play a more important role than those located in the microvillous membrane.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0435-1339
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
511-7
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of epidermal growth factor by different routes of administration on the small intestinal mucosa of rats fed elemental diet.
pubmed:affiliation
Second Department of Internal Medicine, Shiga University of Medical Science, Otsu, Japan.
pubmed:publicationType
Journal Article