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rdf:type |
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lifeskim:mentions |
umls-concept:C0006104,
umls-concept:C0007452,
umls-concept:C0013139,
umls-concept:C0036025,
umls-concept:C0086168,
umls-concept:C0441655,
umls-concept:C0596901,
umls-concept:C0752093,
umls-concept:C1152881,
umls-concept:C1704675,
umls-concept:C2347858
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pubmed:issue |
3
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pubmed:dateCreated |
1993-10-18
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pubmed:abstractText |
Rab GDP dissociation inhibitor (Rab GDI), will induce the dissociation of GDP-bound rab3A from synaptic membranes and will inhibit GDP dissociation from Sec4, a member of the Rab subgroup of the Ras GTPase superfamily which is required for exocytosis in Saccharomyces cerevisiae. We report that Rab GDI releases GDP-bound Sec4 from yeast membranes. dGDI, a Drosophila homologue can similarly inhibit GDP dissociation from Sec4 and release GDP-bound Sec4 from yeast membranes. An activity partially purified from yeast cytosol dissociates GDP-bound Sec4 from yeast membranes, suggesting that yeast also possess a GDI protein that functions to recycle Sec4 from its target membrane.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
331
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8375508-Animals,
pubmed-meshheading:8375508-Brain,
pubmed-meshheading:8375508-Cattle,
pubmed-meshheading:8375508-Cell Membrane,
pubmed-meshheading:8375508-Drosophila melanogaster,
pubmed-meshheading:8375508-Fungal Proteins,
pubmed-meshheading:8375508-GTP-Binding Proteins,
pubmed-meshheading:8375508-Guanine Nucleotide Dissociation Inhibitors,
pubmed-meshheading:8375508-Guanosine 5'-O-(3-Thiotriphosphate),
pubmed-meshheading:8375508-Nerve Tissue Proteins,
pubmed-meshheading:8375508-Protein Binding,
pubmed-meshheading:8375508-Saccharomyces cerevisiae,
pubmed-meshheading:8375508-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:8375508-rab GTP-Binding Proteins
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pubmed:year |
1993
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pubmed:articleTitle |
Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae. Conservation of GDI membrane dissociation activity.
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pubmed:affiliation |
Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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