Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-10-15
pubmed:abstractText
The high mobility group protein HMG I(Y) and the transcription factor NF-kappa B are required for the activity of positive regulatory domain II (PRDII), a virus-inducible regulatory element of the human interferon-beta gene promoter. In this paper we provide evidence that HMG I(Y) is also required for the activity of PRDIV, a regulatory element that synergizes with PRDII. In this case, HMG I(Y) stimulates binding of activating transcription factor 2 (ATF-2) and the assembly of inducible complexes containing ATF-2 and c-Jun. Remarkably, HMG I(Y) also specifically interacts with the leucine zipper/basic region of ATF-2, and ATF-2 in turn interacts with NF-kappa B. We therefore propose that the HMG I(Y) plays a critical structural role in establishing transcriptional synergy between PRDII and PRDIV by promoting the activities and/or binding of NF-kappa B and ATF-2 and by facilitating their interaction.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
887-98
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:8374955-Activating Transcription Factor 2, pubmed-meshheading:8374955-Animals, pubmed-meshheading:8374955-Base Sequence, pubmed-meshheading:8374955-Binding Sites, pubmed-meshheading:8374955-Cyclic AMP Response Element-Binding Protein, pubmed-meshheading:8374955-Enhancer Elements, Genetic, pubmed-meshheading:8374955-Gene Expression Regulation, Viral, pubmed-meshheading:8374955-High Mobility Group Proteins, pubmed-meshheading:8374955-Humans, pubmed-meshheading:8374955-Interferon-beta, pubmed-meshheading:8374955-L Cells (Cell Line), pubmed-meshheading:8374955-Mice, pubmed-meshheading:8374955-Models, Structural, pubmed-meshheading:8374955-Molecular Sequence Data, pubmed-meshheading:8374955-NF-kappa B, pubmed-meshheading:8374955-Plasmids, pubmed-meshheading:8374955-Promoter Regions, Genetic, pubmed-meshheading:8374955-Regulatory Sequences, Nucleic Acid, pubmed-meshheading:8374955-Transcription, Genetic, pubmed-meshheading:8374955-Transcription Factors, pubmed-meshheading:8374955-Transfection
pubmed:year
1993
pubmed:articleTitle
Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements.
pubmed:affiliation
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.