rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1993-10-15
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pubmed:abstractText |
The high mobility group protein HMG I(Y) and the transcription factor NF-kappa B are required for the activity of positive regulatory domain II (PRDII), a virus-inducible regulatory element of the human interferon-beta gene promoter. In this paper we provide evidence that HMG I(Y) is also required for the activity of PRDIV, a regulatory element that synergizes with PRDII. In this case, HMG I(Y) stimulates binding of activating transcription factor 2 (ATF-2) and the assembly of inducible complexes containing ATF-2 and c-Jun. Remarkably, HMG I(Y) also specifically interacts with the leucine zipper/basic region of ATF-2, and ATF-2 in turn interacts with NF-kappa B. We therefore propose that the HMG I(Y) plays a critical structural role in establishing transcriptional synergy between PRDII and PRDIV by promoting the activities and/or binding of NF-kappa B and ATF-2 and by facilitating their interaction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
pubmed:issn |
0092-8674
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
10
|
pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
887-98
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8374955-Activating Transcription Factor 2,
pubmed-meshheading:8374955-Animals,
pubmed-meshheading:8374955-Base Sequence,
pubmed-meshheading:8374955-Binding Sites,
pubmed-meshheading:8374955-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:8374955-Enhancer Elements, Genetic,
pubmed-meshheading:8374955-Gene Expression Regulation, Viral,
pubmed-meshheading:8374955-High Mobility Group Proteins,
pubmed-meshheading:8374955-Humans,
pubmed-meshheading:8374955-Interferon-beta,
pubmed-meshheading:8374955-L Cells (Cell Line),
pubmed-meshheading:8374955-Mice,
pubmed-meshheading:8374955-Models, Structural,
pubmed-meshheading:8374955-Molecular Sequence Data,
pubmed-meshheading:8374955-NF-kappa B,
pubmed-meshheading:8374955-Plasmids,
pubmed-meshheading:8374955-Promoter Regions, Genetic,
pubmed-meshheading:8374955-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:8374955-Transcription, Genetic,
pubmed-meshheading:8374955-Transcription Factors,
pubmed-meshheading:8374955-Transfection
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pubmed:year |
1993
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pubmed:articleTitle |
Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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