Linked Life Data

8374799

Source:http://linkedlifedata.com/resource/pubmed/id/8374799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-10-15
pubmed:abstractText
The development of the folial pattern was studied in the cerebellar vermis of 32 trisomy 19 (Ts19) mice aged 1-16 days postpartum and their euploid littermates. In the Ts19 cerebellum, fissures were formed in the regular sequence observed in control littermates, but their appearance was delayed by about 2 days. Fissure number increased until day 6 in euploid controls and in Ts19 mice, remaining constant thereafter. In Ts19 cerebella, fissure number and fissure depth were reduced significantly; there were 30% fewer Purkinje cells and the cross-sectional areas of the external germinal layer and of the total cerebellar vermis were decreased, reflecting a permanent hypoplasia. Both in Ts19 and control mice, a temporal and quantitative relationship was observed between fissure formation and the expansion of the external germinal layer, whereas the increase in fissure depth was found to correlate with the growth of the whole cerebellar vermis. Determination of the surface folding index revealed that only during fissure formation, the expansion of the cerebellar surface exceeded that of the cerebellar volume. The present study does not give any indication that foliation and histogenesis of the cerebellum are differentially affected by trisomy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0361-9230
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
215-22
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Foliation of the cerebellar vermis in trisomy 19 mice.
pubmed:affiliation
Abteilung für Neuroanatomie, Universitätskrankenhaus Eppendorf, Hamburg, Germany.
pubmed:publicationType
Journal Article