Linked Life Data

8373224

Source:http://linkedlifedata.com/resource/pubmed/id/8373224

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1993-10-8
pubmed:abstractText
Plachitin, which is reconstituted by the combination of CDDP and chitin, has been reported to have a slow releasing property of CDDP and an antitumor effect. The antitumor effect and pharmacokinetics of Plachitin for intraarterial chemoembolization therapy were studied in rabbits using VX2 tumor inoculated in the hind limb. One gram of Plachitin contained 300 mg CDDP, and the form of Plachitin was modified into particles (about 50 microns in diameter). Plachitin was injected into the femoral artery. The study was carried out in four groups. The tumor growth ratio was significantly lower in the Plachitin group than in the CDDP, chitin, and control groups (p < 0.05). Tumor regression was noticed only in the Plachitin group. The tumor platinum (Pt.) level was higher than the serum Pt. level for 5 days after Plachitin injection. From the above results it can be concluded that Plachitin particles released CDDP slowly around the tumor and the tumor growth was suppressed by the additive effect of CDDP and embolization. Plachitin was considered a useful agent for chemoembolization therapy for the cancer patients.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0385-0684
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
1582-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[A new trial of plachitin particles for intraarterial chemoembolization therapy in rabbit].
pubmed:affiliation
2nd Dept. of Surgery, Shimane Medical University.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't