Linked Life Data

8373163

Source:http://linkedlifedata.com/resource/pubmed/id/8373163

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-10-12
pubmed:abstractText
Plasmid-mediated resistance to cadmium occurs by means of energy-dependent efflux mediated by a P-ATPase. Formation by the cadA protein of a phosphorylated enzyme intermediate characteristic of members of this class of enzymes was identified by acid pH-sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The formation of the phosphorylated product is dependent upon the presence of the cadA gene product and cadmium. Zinc does not induce labeling, although the determinant has been reported to confer resistance to that cation. The phosphoenzyme product is acid-stable and labile in the presence of alkali or hydroxylamine. Pulse-chase experiments with unlabeled ATP indicate rapid enzyme turnover. The label is also chased in the presence of ADP, suggesting a reversible reaction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0003-9861
pubmed:author
pubmed:issnType
Print
pubmed:volume
305
pubmed:geneSymbol
cadA
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
267-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Formation of a phosphorylated enzyme intermediate by the cadA Cd(2+)-ATPase.
pubmed:affiliation
Department of Biochemistry, Wayne State University School of Medicine, Detroit, Michigan 48201.
pubmed:publicationType
Journal Article, In Vitro