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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0006137,
umls-concept:C0011298,
umls-concept:C0020094,
umls-concept:C0030481,
umls-concept:C0037928,
umls-concept:C0076560,
umls-concept:C0147139,
umls-concept:C0205210,
umls-concept:C0279477,
umls-concept:C0332281,
umls-concept:C0445581,
umls-concept:C1336626,
umls-concept:C1442734,
umls-concept:C1533179,
umls-concept:C1704619,
umls-concept:C2348519
|
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-10-8
|
| pubmed:abstractText |
In Rio de Janeiro (RJ) most cases of paraparesis of obscure origin are associated with the human T-cell lymphotropic virus type I (HTLV-I). Thirty-four consecutive patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) from RJ were evaluated. Most patients came from low socio-economic levels. There was no difference in terms of gender. The main affected racial group was white. A history of sexually transmitted diseases was a major risk factor for HAM/TSP and a positive serology for syphilis was found in 26.5% of the patients. The major clinical findings were of a spastic paraparesis with generalized brisk tendon jerks and bilateral Babinki's sign. Sensation was abnormal in 25 patients (73.5%) and five (14.7%) had a sensory level. Three patients (8.8%) had optic atrophy. The cerebrospinal fluid showed a lymphocytic pleocytosis with a mean total protein content of 0.4 g/litre, and an increased intrathecal IgG synthesis in 59.4% of patients. HAM/TSP and multiple sclerosis (MS) occur indigenously in RJ and some HAM/TSP cases can be sometimes confused with MS. Therefore we propose that, in places where MS coexist with HAM/TSP, HTLV-I antibodies should be sought routinely in those MS suspected cases with prominent spastic paraparesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0001-6314
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
59-62
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8372632-Adolescent,
pubmed-meshheading:8372632-Adult,
pubmed-meshheading:8372632-Brazil,
pubmed-meshheading:8372632-Cerebrospinal Fluid,
pubmed-meshheading:8372632-Ethnic Groups,
pubmed-meshheading:8372632-Female,
pubmed-meshheading:8372632-Fluorescent Antibody Technique,
pubmed-meshheading:8372632-HTLV-I Antibodies,
pubmed-meshheading:8372632-Humans,
pubmed-meshheading:8372632-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:8372632-Male,
pubmed-meshheading:8372632-Neurologic Examination,
pubmed-meshheading:8372632-Paraparesis, Tropical Spastic,
pubmed-meshheading:8372632-Paresthesia,
pubmed-meshheading:8372632-Reflex, Babinski,
pubmed-meshheading:8372632-Risk Factors,
pubmed-meshheading:8372632-Sex Factors,
pubmed-meshheading:8372632-Sexual Behavior,
pubmed-meshheading:8372632-Sexually Transmitted Diseases,
pubmed-meshheading:8372632-Syphilis
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil.
|
| pubmed:affiliation |
HTLV-associated Neuropathies Unit, Evandro Chagas Hospital, Fiocruz, Brazil.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|