Linked Life Data

8372448

Source:http://linkedlifedata.com/resource/pubmed/id/8372448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-10-14
pubmed:abstractText
The RTVL-H family is a medium repetitive family endogenous retrovirus-like sequences found in the genomes of humans and other primates. Different subfamilies of RTVL-H elements can be identified based on sequence differences clustered within the U3 region of their long terminal repeats (LTRs). These subfamilies have been designated Type I, Type Ia, and Type II. Examination of the U3 repeat structure of the LTR suggests that the Type Ia LTR is a recombinant between Types I and II. Northern analysis of cell lines indicates that expression of RTVL-H elements with Type Ia LTRs is less restricted than the other two LTR types. We have examined the evolutionary history of these subfamilies within the primate lineage through Southern blot analyses and library screening procedures to determine copy numbers and through polymerase chain reaction (PCR) analyses to determine integration times of individual elements at orthologous loci in different primate species. Our findings suggest that the Type I and Type II subfamilies arose early in primate evolution and had undergone their most significant expansions before the divergence of apes and Old World monkeys 30 MYr ago. In contrast, the Type Ia subfamily has expanded more recently, being found in significant numbers only in hominoids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0042-6822
pubmed:author
pubmed:issnType
Print
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
778-88
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Recent evolutionary expansion of a subfamily of RTVL-H human endogenous retrovirus-like elements.
pubmed:affiliation
Terry Fox Laboratory, B.C. Cancer Agency, Vancouver, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't