Linked Life Data

8371502

Source:http://linkedlifedata.com/resource/pubmed/id/8371502

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1993-10-12
pubmed:abstractText
Anti-neutrophil cytoplasmic autoantibodies (ANCA) specific for constituents of neutrophil primary granules were used for enzyme immunosorbent assay in patients with vasculitic syndrome and glomerulonephritis. Proteinase 3 specific ANCA (PR3-ANCA), which include most of cytoplasmic staining pattern ANCA on indirect immunofluorescence assay (IIF) using alcohol-fixed neutrophils, were useful serologic markers for diagnosis of Wegener's granulomatosis and their titers correlated with disease activity. Myeloperoxidase specific ANCA (MPO-ANCA), which include most of perinuclear staining pattern ANCA on IIF, were detected not only in patients with well recognized clinicopathologic vasculitic syndrome and glomerulonephritis, such as microscopic polyarteritis nodosa, allergic granulomatous angitis and idiopathic crescentic necrotizing glomerulonephritis but were also detected in patients with unclassified vasculitis which are difficult to assign to a distinct diagnostic category. Patients with MPO-ANCA had common clinicopathological features, such as rapidly progressive glomerulonephritic syndrome, pulmonary hemorrhage and purpura. Histologically, patients with MPO-ANCA had focal segmental necrotizing glomerulonephritis with various degrees of crescent, pulmonary alveolar hemorrhage and leukocytoclastic vasculitis induced by necrotizing capillaries. A new clinical entity, MPO-ANCA related vasculitis in vasculitic syndrome, is proposed to manage and investigate the pathogenesis of vasculitis.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0047-1860
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
866-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Anti-neutrophil cytoplasmic autoantibody (ANCA) in systemic vasculitic syndrome].
pubmed:affiliation
1st Department of Internal Medicine, Kyorin University, School of Medicine, Mitaka.
pubmed:publicationType
Journal Article, English Abstract, Review