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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1993-10-13
|
| pubmed:abstractText |
To determine if misoprostol (exogenous prostaglandin E1 PGE1) used vaginally was of value in improving the Bishop score, leading to an early safe vaginal delivery in women in whom the cervix is unripe and delivery is indicated.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Americas,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Caribbean,
http://linkedlifedata.com/resource/pubmed/keyword/Cervical Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Cervix,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Trials,
http://linkedlifedata.com/resource/pubmed/keyword/DELIVERY,
http://linkedlifedata.com/resource/pubmed/keyword/Developing Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Double-blind Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia,
http://linkedlifedata.com/resource/pubmed/keyword/Genitalia, Female,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Jamaica,
http://linkedlifedata.com/resource/pubmed/keyword/North America,
http://linkedlifedata.com/resource/pubmed/keyword/OXYTOCIN,
http://linkedlifedata.com/resource/pubmed/keyword/PROSTAGLANDINS,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Pituitary Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy, Third Trimester,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy Outcomes,
http://linkedlifedata.com/resource/pubmed/keyword/Prostaglandins, Synthetic,
http://linkedlifedata.com/resource/pubmed/keyword/Reproduction,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Urogenital System,
http://linkedlifedata.com/resource/pubmed/keyword/Uterus
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0306-5456
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
100
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
641-4
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:otherAbstract |
PIP: A double-blind clinical trial was conducted to determine if misoprostol (exogenous prostaglandin E1 PGE1) used vaginally was of value in improving the Bishop score, leading to an early safe vaginal delivery in women in whom the cervix is unripe and delivery is indicated. 45 women were selected from the antenatal ward and clinic of the University Hospital of the West Indies. All were women in the 3rd trimester of pregnancy who had an indication for induction, an unripe cervix, and no contraindication to prostaglandins. The women were randomly assigned to receive treatment or a placebo. The treated group had 100 mcg misoprostol inserted vaginally, while the placebo was similarly inserted. Efficacy of the misoprostol was measured by the increase in the Bishop score 12 hours after giving the treatment, the time between insertion and delivery, the need for oxytocin, and the outcome of the pregnancy. The prostaglandin was superior to the placebo in ripening the cervix and inducing labor. The change in Bishop score was 5.3 in the misoprostol group compared with 1.5 in the placebo group (P0.001). 8% of patients had no change in their Bishop score in the misoprostol group compared to 62% in the placebo group (P0.001). The mean time from insertion to delivery was 15.6 hours in the former while it was 43.2 hours in the placebo group (P=0.001). 29% of women receiving misoprostol needed oxytocin compared with 62% of those who received the placebo (P0.02). There was no difference in the 2 groups in the delivery outcome in terms of complications, Apgar scores, and mode of delivery. There were no significant changes in maternal vital signs in both groups. Fetal distress, as evidenced by the presence of meconium stained amniotic fluid or fetal tachycardia, was similar in both groups. Polystole (more than 5 contractions in 10 minutes occurred in 1 woman in the misoprostol group. Extra-amniotic misoprostol is a cheap, effective, and safe prostaglandin for cervical ripening.
|
| pubmed:meshHeading |
pubmed-meshheading:8369246-Administration, Intravaginal,
pubmed-meshheading:8369246-Adult,
pubmed-meshheading:8369246-Cervix Uteri,
pubmed-meshheading:8369246-Double-Blind Method,
pubmed-meshheading:8369246-Female,
pubmed-meshheading:8369246-Humans,
pubmed-meshheading:8369246-Labor, Induced,
pubmed-meshheading:8369246-Misoprostol,
pubmed-meshheading:8369246-Pregnancy,
pubmed-meshheading:8369246-Pregnancy Trimester, Third
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Intravaginal misoprostol as a cervical ripening agent.
|
| pubmed:affiliation |
Department of Obstetrics and Gynaecology, University of the West Indies, Kingston, Jamaica.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|