Linked Life Data

8367619

Source:http://linkedlifedata.com/resource/pubmed/id/8367619

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-10-6
pubmed:abstractText
Effects of histamine on the base-line activity of vagal pulmonary C-fibers and their responses to chemical and mechanical stimulations were studied in anesthetized, open-chest dogs. Histamine aerosols (5 breaths, 1% solution) increased the change in tracheal pressure per breath (delta Pt) to 53 +/- 9% (mean +/- SE) above its base line, whereas an accompanying increase in activity was found in only 27% of the C-fibers studied and hence the overall afferent activity was not significantly different from the control. After Pt returned toward the base line in several minutes, the receptor activity evoked by right atrial injection of capsaicin (0.8-4.0 micrograms/kg) increased from a base line of 0.43 +/- 0.02 imp/sec to 8.12 +/- 1.16 imp/sec (averaged over 10 sec), which was markedly greater and longer lasting than the response triggered by the same dose of capsaicin after phosphate buffer aerosols (4.72 +/- 0.71 imp/sec). Furthermore, pretreatment with histamine aerosols also enhanced the afferent responses of these receptors to static lung inflation (Pt = 20 cmH2O). We conclude that the low dose of histamine aerosols alone did not consistently stimulate the vagal pulmonary C-fibers, but it potentiated the stimulatory effects of both capsaicin and lung inflation on these receptors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0034-5687
pubmed:author
pubmed:issnType
Print
pubmed:volume
93
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-96
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Histamine enhances vagal pulmonary C-fiber responses to capsaicin and lung inflation.
pubmed:affiliation
Department of Physiology and Biophysics, University of Kentucky, Lexington 40536-0084.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't