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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-10-1
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pubmed:abstractText |
Controlled Smith degradation of ukonan C, a phagocytosis-activating polysaccharide isolated from the rhizome of Curcuma longa L., was performed. The reticuloendothelial system-potentiating, anti-complementary and alkaline phosphatase-inducing activities of ukonan C and its degradation products were investigated. Methylation analyses of the primary and secondary Smith degradation products and of a de-arabinosylated product indicated that structural features of the arabinogalactan core of ukonan C include a backbone chain composed of beta-1,3-linked D-galactose and beta-1,4-linked D-xylose. All of the galactose units in the backbone carry side chains composed of beta-1,6-linked D-galactosyl residues with or without terminal alpha-L-arabinose units at position 3. Ukonan C showed remarkable effects on both reticuloendothelial system-potentiating and alkaline phosphatase-inducing activities. Periodate oxidation caused a decrease in or disappearance of the immunological activities, but the controlled Smith degradation product having the arabinogalactan core structure of polysaccharide showed a pronounced effect on anti-complementary activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0918-6158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:8364466-Adult,
pubmed-meshheading:8364466-Alkaline Phosphatase,
pubmed-meshheading:8364466-Animals,
pubmed-meshheading:8364466-Carbohydrate Sequence,
pubmed-meshheading:8364466-Chromatography, Gel,
pubmed-meshheading:8364466-Complement Inactivator Proteins,
pubmed-meshheading:8364466-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:8364466-Galactans,
pubmed-meshheading:8364466-Humans,
pubmed-meshheading:8364466-Hydrolysis,
pubmed-meshheading:8364466-Male,
pubmed-meshheading:8364466-Methylation,
pubmed-meshheading:8364466-Mice,
pubmed-meshheading:8364466-Mice, Inbred ICR,
pubmed-meshheading:8364466-Molecular Sequence Data,
pubmed-meshheading:8364466-Mononuclear Phagocyte System,
pubmed-meshheading:8364466-Phagocytosis,
pubmed-meshheading:8364466-Plants, Medicinal,
pubmed-meshheading:8364466-Polysaccharides,
pubmed-meshheading:8364466-Polysaccharides, Bacterial
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pubmed:year |
1993
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pubmed:articleTitle |
Arabinogalactan core structure and immunological activities of ukonan C, an acidic polysaccharide from the rhizome of Curcuma longa.
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pubmed:affiliation |
Kyoritsu College of Pharmacy, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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