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pubmed:abstractText |
The prenatal hemic hypoxia was caused by methemoglobin inducing agent, sodium nitrite, injected intraperitoneally in different doses from 10th to 19th day of pregnancy. It was shown that perinatal hemic hypoxia evoked delayed neurological deficit (disorders of motor coordination, hypodynamia) and disturbances of mnestic functions (impairment of learning and memory in passive and active avoidance paradigms and in the test of extrapolative water escape). The most pronounced disorders of CNS functions were shown in offsprings of male rats injected with sodium nitrite in a dose of 40 mg/kg.
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