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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1993-9-30
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pubmed:abstractText |
Specialized Barrett's esophageal mucosa, characterized by incomplete intestinal metaplasia of the esophageal mucosa, is associated with the development of adenocarcinoma. Although the intestinal disaccharidase sucrase-isomaltase (SI) has been shown in incomplete intestinal metaplasia of the stomach, it is commonly believed that Barrett's mucosa does not express SI based on the lack of enzymatic activity. This study was undertaken to determine whether the SI gene is expressed in Barrett's epithelium and its associated adenocarcinoma at the level of messenger RNA (mRNA) and protein.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0016-5085
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
105
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pubmed:geneSymbol |
SI
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
837-44
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8359653-Adenocarcinoma,
pubmed-meshheading:8359653-Aged,
pubmed-meshheading:8359653-Barrett Esophagus,
pubmed-meshheading:8359653-Base Sequence,
pubmed-meshheading:8359653-DNA, Neoplasm,
pubmed-meshheading:8359653-Epithelial Cells,
pubmed-meshheading:8359653-Epithelium,
pubmed-meshheading:8359653-Esophageal Neoplasms,
pubmed-meshheading:8359653-Esophagus,
pubmed-meshheading:8359653-Female,
pubmed-meshheading:8359653-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:8359653-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8359653-Humans,
pubmed-meshheading:8359653-Immunohistochemistry,
pubmed-meshheading:8359653-Male,
pubmed-meshheading:8359653-Molecular Sequence Data,
pubmed-meshheading:8359653-Mucous Membrane,
pubmed-meshheading:8359653-Phenotype,
pubmed-meshheading:8359653-Polymerase Chain Reaction,
pubmed-meshheading:8359653-RNA, Messenger,
pubmed-meshheading:8359653-Sucrase-Isomaltase Complex,
pubmed-meshheading:8359653-Transcription, Genetic
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pubmed:year |
1993
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pubmed:articleTitle |
Sucrase-isomaltase gene expression in Barrett's esophagus and adenocarcinoma.
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pubmed:affiliation |
Department of Internal Medicine, University of Pennsylvania School of Medicine, Philadelphia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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