Linked Life Data

8355619

Source:http://linkedlifedata.com/resource/pubmed/id/8355619

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-9-17
pubmed:databankReference
pubmed:abstractText
The presence of M protein on the surface of group A streptococci (GAS) confers the ability of the cell to resist phagocytosis in the absence of type-specific antibodies. It undergoes antigenic variation with more than 80 different serotypes having been defined. We have sequenced the M protein gene (emm1.1) from strain CS190 and present evidence that individual nucleotide substitutions are responsible for sequence variation in the N-terminal non-repeat region of emm1.1 and these substitutions have altered antibody recognition of opsonic epitopes. The N-terminal non-repeat domains of two other closely related strains, 71-155 and 76-088, were found to have sequence identical to emm1.1 with the addition of a 21 bp insert. This study provides the first evidence that nucleotide substitutions and small insertions are responsible for size and antigenic variation in the N-terminal non-repeat domain of the M protein of GAS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0950-382X
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:geneSymbol
emm1.0, emm1.1, emm1.2, emm12, emm6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
981-91
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Nucleotide substitutions and small-scale insertion produce size and antigenic variation in group A streptococcal M1 protein.
pubmed:affiliation
Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108.
pubmed:publicationType
Journal Article, Comparative Study