Linked Life Data

8355597

Source:http://linkedlifedata.com/resource/pubmed/id/8355597

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-9-17
pubmed:databankReference
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94693, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94694, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94695, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94696, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94697, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94698, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94699, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94700, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94701, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94702, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94703, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94704, http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M94705
pubmed:abstractText
L1 retroposons are represented in mice by subfamilies of interspersed sequences of varied abundance. Previous analyses have indicated that subfamilies are generated by duplicative transposition of a small number of members of the L1 family, the progeny of which then become a major component of the murine L1 population, and are not due to any active processes generating homology within preexisting groups of elements in a particular species. In mice, more than a third of the L1 elements belong to a clade that became active approximately 5 Mya and whose elements are > or = 95% identical. We have collected sequence information from 13 L1 elements isolated from two species of voles (Rodentia: Microtinae: Microtus and Arvicola) and have found that divergence within the vole L1 population is quite different from that in mice, in that there is no abundant subfamily of homologous elements. Individual L1 elements from voles are very divergent from one another and belong to a clade that began a period of elevated duplicative transposition approximately 13 Mya. Sequence analyses of portions of these divergent L1 elements (approximately 250 bp each) gave no evidence for concerted evolution having acted on the vole L1 elements since the split of the two vole lineages approximately 3.5 Mya; that is, the observed interspecific divergence (6.7%-24.7%) is not larger than the intraspecific divergence (7.9%-27.2%), and phylogenetic analyses showed no clustering into Arvicola and Microtus clades.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0737-4038
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
719-31
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
A major difference between the divergence patterns within the lines-1 families in mice and voles.
pubmed:affiliation
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't