| pubmed-article:8349596 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8349596 | lifeskim:mentions | umls-concept:C1180347 | lld:lifeskim |
| pubmed-article:8349596 | lifeskim:mentions | umls-concept:C0017362 | lld:lifeskim |
| pubmed-article:8349596 | lifeskim:mentions | umls-concept:C0034987 | lld:lifeskim |
| pubmed-article:8349596 | lifeskim:mentions | umls-concept:C0171040 | lld:lifeskim |
| pubmed-article:8349596 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:8349596 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:8349596 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:8349596 | pubmed:dateCreated | 1993-9-15 | lld:pubmed |
| pubmed-article:8349596 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8349596 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8349596 | pubmed:abstractText | hXBP-1 is a transcription factor of the leucine zipper (b-zip) family important in the expression of the class II major histocompatibility complex gene, DRA. Studies with mouse-human hybrids have mapped hXBP-1 hybridizing fragments to human chromosomes 5 and 22 and the frequent detection of two mRNA transcripts suggested that hXBP-1 may be a member of a small gene family. To analyze the structure and regulation of hXBP-1 further, cosmid clones from both chromosomes were isolated. Mapping and sequence analyses reveal that chromosome 22 contains the functional hXBP-1 gene while chromosome 5 contains a processed pseudogene. hXBP-1 promoter analysis has revealed that cis-active elements within the 5'-untranslated region of hXBP-1 are essential for full promoter activity. One such element, hX2, is identical to the hXBP-1 target sequence in the DRA promoter. Mutagenesis of the hX2 site substantially decreases promoter activity. This element interacts with four distinct protein complexes in mature B cells and cross-competition experiments show that two of these complexes (complex 1 and complex 4) also interact with the hXBP-1 target sequence (X2) from the DRA promoter. The similarities of the hXBP-1 promoter and of the DRA promoter (the gene that the hXBP-1 protein regulates) are further emphasized by the fact that a Y box element is located 3' of both hX2 and X2. | lld:pubmed |
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| pubmed-article:8349596 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8349596 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8349596 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8349596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8349596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8349596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8349596 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8349596 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8349596 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8349596 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:8349596 | pubmed:author | pubmed-author:StromingerJ... | lld:pubmed |
| pubmed-article:8349596 | pubmed:author | pubmed-author:GlimcherL HLH | lld:pubmed |
| pubmed-article:8349596 | pubmed:author | pubmed-author:FastCC | lld:pubmed |
| pubmed-article:8349596 | pubmed:author | pubmed-author:PonathP DPD | lld:pubmed |
| pubmed-article:8349596 | pubmed:author | pubmed-author:LashP RPR | lld:pubmed |
| pubmed-article:8349596 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8349596 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8349596 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:8349596 | pubmed:geneSymbol | hXBP-1 | lld:pubmed |
| pubmed-article:8349596 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8349596 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8349596 | pubmed:pagination | 17074-82 | lld:pubmed |
| pubmed-article:8349596 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:8349596 | pubmed:meshHeading | pubmed-meshheading:8349596-... | lld:pubmed |
| pubmed-article:8349596 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8349596 | pubmed:articleTitle | The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes. | lld:pubmed |
| pubmed-article:8349596 | pubmed:affiliation | Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138. | lld:pubmed |
| pubmed-article:8349596 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8349596 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8349596 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:7494 | entrezgene:pubmed | pubmed-article:8349596 | lld:entrezgene |
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