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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1993-9-10
|
| pubmed:abstractText |
Experimentally, Gram-negative septic shock can be prevented by the prophylactic use of an anti-TNF-alpha monoclonal antibody. The clinical similarity between Gram-negative and Gram-positive septic shock suggested that anti-TNF-alpha therapy might have a wide application. Increased levels of TNF-alpha were seen in a murine model of septic shock due to Streptococcus pyogenes but administration of an anti-TNF-alpha monoclonal antibody had no beneficial effect on the outcome.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0378-1097
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
175-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8349091-Animals,
pubmed-meshheading:8349091-Antibodies, Monoclonal,
pubmed-meshheading:8349091-Clindamycin,
pubmed-meshheading:8349091-Combined Modality Therapy,
pubmed-meshheading:8349091-Drug Evaluation, Preclinical,
pubmed-meshheading:8349091-Immunotherapy,
pubmed-meshheading:8349091-Male,
pubmed-meshheading:8349091-Mice,
pubmed-meshheading:8349091-Shock, Septic,
pubmed-meshheading:8349091-Streptococcal Infections,
pubmed-meshheading:8349091-Streptococcus pyogenes,
pubmed-meshheading:8349091-Treatment Failure,
pubmed-meshheading:8349091-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Effect of anti-TNF-alpha treatment in an antibiotic treated murine model of shock due to Streptococcus pyogenes.
|
| pubmed:affiliation |
Department of Infectious Diseases and Bacteriology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|