Linked Life Data

8348761

Source:http://linkedlifedata.com/resource/pubmed/id/8348761

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1993-9-13
pubmed:abstractText
The major objective of noninvasive imaging for detection of myocardial viability is to assist in the improved selection of patients with coronary artery disease and severe left ventricular dysfunction who would benefit most from revascularization. The techniques most commonly used to identify viable myocardium are thallium-201 (201Tl) scintigraphy, positron emission tomography (PET) using a flow tracer in combination with a metabolic tracer, technetium-99m (99mTc) sestamibi imaging, and dobutamine echocardiography. On stress 201Tl scintigraphy, asynergic regions showing normal thallium uptake, an initial defect with delayed redistribution at 3-4 h, late redistribution at 24 h, or defect reversibility after reinjection of a second dose of 201Tl at rest all suggest preserved viability. The greater the final uptake of 201Tl in areas of regional myocardial dysfunction preoperatively, the greater the improvement in ejection fraction after coronary revascularization. Demonstration of uptake of fluoro-18 deoxyglucose (FDG) in regions of diminished blood flow on PET imaging also correlates well with improved systolic function after revascularization. 99mTc sestamibi may also be useful for assessment of myocardial viability, particularly after thrombolytic therapy for acute myocardial infarction. Dobutamine echocardiography has good positive predictive value for viability determination, but absence of systolic thickening in an akinetic zone in response to intravenous infusion of the drug may still be associated with viable myocardium in 25-50% of segments. Of all the techniques cited above, quantitative resting 201Tl scintigraphy may be the best approach for distinguishing between viable and irreversibly injured myocardium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0160-9289
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
531-8
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The noninvasive assessment of myocardial viability.
pubmed:affiliation
Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908.
pubmed:publicationType
Journal Article, Review