Linked Life Data

8347924

Source:http://linkedlifedata.com/resource/pubmed/id/8347924

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1993-9-16
pubmed:abstractText
The chromosome of Y. enterocolitica encodes a heat-stable enterotoxin, Yst, being related to STI. The capacity to produce Yst generally disappears during storage of the strains. In these strains, the yst gene is intact but remains silent. The pYV plasmid encodes the eleven secreted antihost proteins called Yops as well as the outer membrane protein YadA. The Yops are secreted by a novel, pYV-encoded secretion mechanism. This mechanism which does not involve the removal of an N-terminal signal sequence, is encoded by the pYV virA and virC loci. The virC locus contains 13 genes called yscA-M. The virA locus encodes the LcrD membrane protein. The yop, yadA and ysc genes form the yop regulon controlled by transcriptional activator VirF. Transcription of the yop, yadA, ysc and virF genes is controlled by temperature. A chromosome-encoded histone-like protein, called YmoA, is involved in the thermoregulation of the yop regulon, which suggests that this thermoregulation could result from temperature-induced changes in DNA topology. The phenotype of ymoA mutants resembles that of osmZ or drdX mutants of E. coli but YmoA is not the Yersinia homologue of the E. coli histone H1. The YmoA histone is also involved in the silencing of the yst gene.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0934-8840
pubmed:author
pubmed:issnType
Print
pubmed:volume
278
pubmed:geneSymbol
virF, yadA, yop, ysc, yst
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-64
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Role of the transcription activator virF and the histone-like protein YmoA in the thermoregulation of virulence functions in yersiniae.
pubmed:affiliation
Microbial Pathogenesis Unit, Université Catholique de Louvain, Brussels, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't