Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1993-9-7
pubmed:abstractText
The existence of water-selective channels has been postulated to explain the high water permeability of erythrocytes and certain epithelial cells. The aquaporin CHIP (channel-forming integral membrane protein of 28 kDa), a molecular water channel, is abundant in erythrocytes and water-permeable segments of the nephron. To determine whether CHIP may mediate transmembrane water movement in other water-permeable epithelia, membranes of multiple organs were studied by immunoblotting, immunohistochemistry, and immunoelectron microscopy using affinity-purified anti-CHIP IgG. The apical membrane of the choroid plexus epithelium was densely stained, implying a role for CHIP in the secretion of cerebrospinal fluid. In the eye, CHIP was abundant in apical and basolateral domains of ciliary epithelium, the site of aqueous humor secretion, and also in lens epithelium and corneal endothelium. CHIP was detected in membranes of hepatic bile ducts and water-resorptive epithelium of gall bladder, suggesting a role in bile secretion and concentration. CHIP was not detected in glandular epithelium of mammary, salivary, or lacrimal glands, suggesting the existence of other water-channel isoforms. CHIP was also not detected within the epithelium of the gastrointestinal mucosa. CHIP was abundant in membranes of intestinal lacteals and continuous capillaries in diverse tissues, including cardiac and skeletal muscle, thus providing a molecular explanation for the known water permeability of certain lymphatics and capillary beds. These studies underscore the hypothesis that CHIP plays a major role in transcellular water movement throughout the body.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-1280133, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-1282299, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-1373524, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-1508193, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-1510932, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-1526967, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-1722319, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-1733238, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-2007592, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-3003182, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-3049610, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-3761362, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-6322657, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-7677994, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-7678419, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-8421053, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-8429910, http://linkedlifedata.com/resource/pubmed/commentcorrection/8346245-8506291
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7275-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia.
pubmed:affiliation
Department of Cell Biology, University of Aarhus, Denmark.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't