Linked Life Data

8345086

Source:http://linkedlifedata.com/resource/pubmed/id/8345086

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-9-8
pubmed:abstractText
Experiments were performed to determine time and dose-dependent effects of clomiphene citrate on the function of fertile donor spermatozoa. The percentages of acrosome-reacted, motile and live spermatozoa were assessed. Incubation with clomiphene citrate (1-1000 mumol/l; 1-4 h) induced a dose- and time-dependent increase in the percentage of acrosome-reacted spermatozoa (up to 100%). Acrosome reaction was associated with an impairment of both motility and viability. The maximal value for percentage of live reacted spermatozoa (37 +/- 1%) was obtained when cells were incubated for 1 h with 100 mumol/l of clomiphene citrate. Oestradiol neither affected sperm function when used alone nor inhibited clomiphene action. These results show that clomiphene strongly triggers the acrosome reaction, but that this action is not related to its anti-oestrogenic properties.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0268-1161
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
922-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of clomiphene citrate on sperm cell function.
pubmed:affiliation
Centre de Fécondation In Vitro, CHU La Grave, France.
pubmed:publicationType
Journal Article, In Vitro