Linked Life Data

8342073

Source:http://linkedlifedata.com/resource/pubmed/id/8342073

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Suppl 4
pubmed:dateCreated
1993-9-1
pubmed:abstractText
Total body irradiation (TBI) is a common component of many preparative regimens used prior to bone marrow transplantation. The biologic effects of TBI are influenced by a number of factors, including total dose, dose fractionation, dose rate, and dose distribution. Higher doses of TBI result in greater antileukemic activity, but this effect may be offset by concomitant increases in treatment-related toxicities. Increased doses of TBI also produce a greater degree of immunosuppression. Fractionated TBI results in decreased late toxicities and immunosuppressive effects when compared with single-dose TBI, yet the extent of marrow ablation seems to be similar. For both single-dose and fractionated TBI, higher dose rates produce increased treatment-related toxicities. Dose rates also may affect marrow ablation and immunosuppression. By targeting radiation to leukemic or immunocompetent cells, alterations in dose distribution have the potential to significantly improve the clinical benefits of TBI. Directed external beam irradiation is one approach to achieving the goal of targeted therapy. Other approaches involve the conjugation of radionuclides to antibodies that recognize specific cell-surface antigens or to aminophosphonic acid compounds that bind to bone. Such specific targeting of radiation could lead to significant increases in the intensity of therapy without resulting in greater treatment-related toxicities.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0093-7754
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3-10; quiz 11
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
The influence of total dose, fractionation, dose rate, and distribution of total body irradiation on bone marrow transplantation.
pubmed:affiliation
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104-2092.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review