Linked Life Data

8341428

Source:http://linkedlifedata.com/resource/pubmed/id/8341428

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-9-2
pubmed:abstractText
Neurons containing calcitonin gene-related peptide in the medial preoptic nucleus exhibit the largest neurochemically defined sex difference in the rat preoptic area with a 20-fold difference in cell numbers. The gonadal steroid hormones responsible for this sexual dimorphism have been investigated by examining calcitonin gene-related peptide immunoreactivity in the preoptic area of adult rats receiving a variety of perinatal and adult gonadal steroid manipulations. Cells immunoreactive for calcitonin gene-related peptide were examined in two populations within the preoptic area, one in its ventrolateral aspect and the other located in the lateral division of the medial preoptic nucleus. Cell profile counts estimate numbers of calcitonin gene-related peptide-containing cells in the medial preoptic nucleus of the female to be 22.2 +/- 3.0 cells/section compared with 1.0 +/- 0.2 in the male (P < 0.01). No sex differences existed in the preoptic ventrolateral population of calcitonin gene-related peptide cells (males 4.3 +/- 0.2, females 4.4 +/- 0.6 cells/section). Gonadectomy of male rats on postnatal day 2 resulted in the appearance of a calcitonin gene-related peptide-containing cell population in the medial preoptic nucleus which was indistinguishable from intact female rats (19.3 +/- 2.2 cells/section). Gonadectomy of adult male rats resulted in a modest increase in calcitonin gene-related peptide cell numbers within the medial preoptic nucleus (8.8 +/- 0.4 cells/section) and this was fully reversed by replacement of testosterone (0.7 +/- 0.2 cells/section).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
991-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Perinatal and adult factors responsible for the sexually dimorphic calcitonin gene-related peptide-containing cell population in the rat preoptic area.
pubmed:affiliation
Department of Neurobiology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't