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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
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|
pubmed:dateCreated |
1993-8-30
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|
pubmed:abstractText |
The amplification of the action of aldosterone by 19-oxoandrost-4-ene-3,17-dione (19-oxo-A-dione) was evaluated by mineralocorticoid bioassays using adrenalectomized rats. Pretreatment of rats with 19-oxo-A-dione did not cause any significant change in urinary Na/K ratio. However, aldosterone caused a significantly lower urinary Na/K ratio and Na excretion in rats pretreated with 19-oxo-A-dione than in rats without pretreatment. These results indicate that the sodium-retaining action of aldosterone is amplified by pretreatment with 19-oxo-A-dione.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jul
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|
pubmed:issn |
0960-0760
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
69-72
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8338792-Adrenalectomy,
pubmed-meshheading:8338792-Aldosterone,
pubmed-meshheading:8338792-Androstenedione,
pubmed-meshheading:8338792-Animals,
pubmed-meshheading:8338792-Drug Synergism,
pubmed-meshheading:8338792-Male,
pubmed-meshheading:8338792-Potassium,
pubmed-meshheading:8338792-Rats,
pubmed-meshheading:8338792-Rats, Sprague-Dawley,
pubmed-meshheading:8338792-Sodium
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|
pubmed:year |
1993
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|
pubmed:articleTitle |
19-Oxoandrost-4-ene-3,17-dione amplifies the action of aldosterone.
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pubmed:affiliation |
Third Department of Internal Medicine, University of Tokyo, Faculty of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
