Linked Life Data

8338670

Source:http://linkedlifedata.com/resource/pubmed/id/8338670

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-9-2
pubmed:abstractText
M-current is widespread in the nervous system. It stabilizes cell excitability, and its suppression by muscarinic receptor activation underlies slow synaptic transmission in sympathetic neurons. Suppression of M-current was one of the first examples of neuromodulation of a potassium current, but the mechanism is not understood. Single-channel recording was used to study this issue. An M-channel with two conductance states, which exhibited appropriate voltage-dependent kinetics with two modes of gating, has been resolved. Mode 1 comprises short open time, low open probability events, and mode 2 openings represent long open time, high open probability behavior. Muscarine decreased M-channel activity by selectively reducing mode 2 M-channel gating through a diffusible second messenger. It is suggested that control of modal gating may be a widespread mechanism for neuromodulation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-84
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Selective reduction of one mode of M-channel gating by muscarine in sympathetic neurons.
pubmed:affiliation
Department of Neurobiology and Behavior, SUNY, Stony Brook 11794.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.