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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1993-8-26
|
| pubmed:abstractText |
Formalin-fixed, paraffin-embedded surgical specimens from 137 primary central nervous system tumors, including 26 astrocytomas (21 fibrillary, 1 protoplasmic, 1 gemistocytic and 3 pilocytic), 26 anaplastic astrocytomas, 9 glioblastomas, 1 gliosarcoma, 8 oligodendrogliomas, 4 ependymomas, 1 anaplastic ependymoma, 2 subependymomas, 3 paragangliomas, and 57 meningiomas, were immunostained with the CM1 polyclonal (pAb) and the DO-7 monoclonal (mAb) antibodies against the p53 protein, using the streptavidin/peroxidase method. In addition, two series of 17 and 9 medulloblastomas were also immunostained with the above pAb and mAb, respectively. p53 protein expression was observed in 7 fibrillary astrocytomas, 17 anaplastic astrocytomas, 5 glioblastomas, 1 gliosarcoma, 1 oligodendroglioma, 1 anaplastic ependymoma, and 4 meningiomas with the CM1 pAb. An additional 10 cases (i.e., 3 anaplastic astrocytomas and 7 meningiomas) were found to be p53 protein positive with the DO-7 mAb. Of the medulloblastomas, 8 (of the 17) and 4 (of the 9) were found to express p53 protein with CM1 pAb and DO-7 mAb, respectively. Our results indicate that p53 protein is expressed in a number of central nervous system neoplasms, and suggest that in astrocytic tumors a possible association may exist between p53 protein expression and tumor progression through increasing histological grades of malignancy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0001-6322
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
85
|
| pubmed:geneSymbol |
p53
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
611-6
|
| pubmed:dateRevised |
2007-11-9
|
| pubmed:meshHeading |
pubmed-meshheading:8337939-Antibodies, Monoclonal,
pubmed-meshheading:8337939-Astrocytoma,
pubmed-meshheading:8337939-Central Nervous System Neoplasms,
pubmed-meshheading:8337939-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8337939-Genes, p53,
pubmed-meshheading:8337939-Glioma,
pubmed-meshheading:8337939-Humans,
pubmed-meshheading:8337939-Immunohistochemistry,
pubmed-meshheading:8337939-Medulloblastoma,
pubmed-meshheading:8337939-Meningioma,
pubmed-meshheading:8337939-Oligodendroglioma,
pubmed-meshheading:8337939-Paraffin Embedding,
pubmed-meshheading:8337939-Tumor Suppressor Protein p53
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
p53 protein expression in central nervous system tumors: an immunohistochemical study with CM1 polyvalent and DO-7 monoclonal antibodies.
|
| pubmed:affiliation |
Sandoz Pharma Ltd., Department of Toxicology, Basel, Switzerland.
|
| pubmed:publicationType |
Journal Article
|