Linked Life Data

8336515

Source:http://linkedlifedata.com/resource/pubmed/id/8336515

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-8-24
pubmed:abstractText
Albino Swiss male mice were inoculated with Trypanosoma cruzi, Tulahuen strain trypomastigotes, and separated into three groups: control, without treatment; control, treated with Nifurtimox 25 mg/day; and experimental, treated with total brain gangliosides 1 mg/day, intramuscular. The treatment was started immediately after infection and maintained for 4 weeks. Parasitemia was determined twice a week and histopathological analyses of hearts were performed. The parasitemia was significantly lowered by the ganglioside treatment. All untreated mice died by day 14 post infection. Survival at day 30 was 96% for mice in the experimental group. Hearts from untreated animals showed acute chagasic myocarditis, while those from mice treated with gangliosides presented only minor mononuclear infiltration. The effect of gangliosides is probably due to interference of parasite penetration into the host cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
PL69-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of gangliosides on Trypanosoma cruzi infection in mice.
pubmed:affiliation
Cátedra de Química Biológica, Facultad de Ciencias Médicas, Universidad Nacional Córdoba, Córdoba, Argentina.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't