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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1993-8-26
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pubmed:abstractText |
The synthesis and biological evaluation of a series of antiplatelet 2-morpholinylchromones has been described. Modification of the C-7 phenylmethoxy group of 8-methyl-7-(phenylmethoxy)-2-(4-morpholinyl)-4H-1-benzopyran-4-one (2) has led to the discovery of a series of 7-[(amino-ethyl)oxy]-8-methyl derivatives which are potent inhibitors of ADP-induced platelet aggregation. Several members of this class proved active in preventing platelet-dependent thrombus formation in the dog, including 8-methyl-7-[2-(4-methyl-1-piperazinyl)ethoxy]-2-(4- morpholinyl)-4H-1-benzopyran-4-one (39) which was devoid of hemodynamic effects at the effective antithrombotic dose.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2623
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
2026-32
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8336341-Adenosine Diphosphate,
pubmed-meshheading:8336341-Animals,
pubmed-meshheading:8336341-Chromones,
pubmed-meshheading:8336341-Dogs,
pubmed-meshheading:8336341-Female,
pubmed-meshheading:8336341-Humans,
pubmed-meshheading:8336341-Male,
pubmed-meshheading:8336341-Morpholines,
pubmed-meshheading:8336341-Piperazines,
pubmed-meshheading:8336341-Platelet Aggregation,
pubmed-meshheading:8336341-Platelet Aggregation Inhibitors,
pubmed-meshheading:8336341-Structure-Activity Relationship
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pubmed:year |
1993
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pubmed:articleTitle |
Synthesis and biological evaluation of antiplatelet 2-aminochromones.
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pubmed:affiliation |
Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001.
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pubmed:publicationType |
Journal Article
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