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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1993-8-26
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pubmed:abstractText |
The synthesis and antimicrobial activity of several new 1-carba-1-dethiacephalosporins is described. The discovery of unique activity of some of the analogues against methicillin-resistant Staphylococcus aureus led to the development of a structure-activity relationship designed to optimize this activity. The results of this investigation along with the pharmacokinetic characteristics of select compounds are described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-2623
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
9
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|
pubmed:volume |
36
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
N
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pubmed:pagination |
1971-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8336336-Animals,
pubmed-meshheading:8336336-Anti-Bacterial Agents,
pubmed-meshheading:8336336-Blood Proteins,
pubmed-meshheading:8336336-Cephalosporins,
pubmed-meshheading:8336336-Half-Life,
pubmed-meshheading:8336336-Humans,
pubmed-meshheading:8336336-Macaca mulatta,
pubmed-meshheading:8336336-Male,
pubmed-meshheading:8336336-Methicillin Resistance,
pubmed-meshheading:8336336-Mice,
pubmed-meshheading:8336336-Mice, Inbred ICR,
pubmed-meshheading:8336336-Microbial Sensitivity Tests,
pubmed-meshheading:8336336-Rats,
pubmed-meshheading:8336336-Rats, Sprague-Dawley,
pubmed-meshheading:8336336-Staphylococcus aureus,
pubmed-meshheading:8336336-Structure-Activity Relationship
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pubmed:year |
1993
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pubmed:articleTitle |
Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus.
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pubmed:affiliation |
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
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pubmed:publicationType |
Journal Article
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