Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1 Pt 1
|
| pubmed:dateCreated |
1993-8-25
|
| pubmed:abstractText |
A 62-year-old man presented with a 4-year history of a pruritic erythematous rash. Initial workup was not diagnostic, and the rash was refractory to standard treatment. A complete blood cell count demonstrated a white cell count of 9100 cells/microliter with 61% polymorphonuclear neutrophils, 16% eosinophils, and 17% lymphocytes. A serum protein electrophoresis revealed an M spike identified as IgG kappa. His IgE level was 11,900 IU/ml. A bone marrow biopsy specimen demonstrated "atypical plasma cells" but was not diagnostic for myeloma. Peripheral blood smear was remarkable for highly convoluted lymphoid cells diagnostic for Sézary T cells. Consistent with this diagnosis, 89% of his peripheral blood CD2+ cells expressed CD4. The eosinophilia, elevated IgE level, and monoclonal gammopathy led to further investigations. Circulating adherent monocytes were 96% positive for presumed low-affinity IgE receptor expression as shown by surface IgE binding. In a 9-day lymphocyte coculture, the patient's T lymphocytes induced IgE production in vitro (1.25 ng/ml) by a normal donor's cultured B cells. A healthy donor's T cells failed to induce IgE production (0 ng/ml) in a similar culture system. In situ hybridization with an Sulfur-35-labeled cDNA probe revealed interleukin-4 mRNA expression by 84% and interleukin-2 mRNA expression by 62% of nonadherent peripheral blood mononuclear cells. Interleukin-5 mRNA was shown by reverse transcription and the polymerase chain reaction. These studies demonstrate a subject with Sézary T cell leukemia with hypereosinophilia and elevated IgE due to presumed enhanced interleukin-4 and interleukin-5 production by the Sézary T cells.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0091-6749
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
92
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
123-31
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8335848-B-Lymphocytes,
pubmed-meshheading:8335848-Biopsy,
pubmed-meshheading:8335848-Bone Marrow,
pubmed-meshheading:8335848-Chronic Disease,
pubmed-meshheading:8335848-Cytokines,
pubmed-meshheading:8335848-DNA,
pubmed-meshheading:8335848-Eosinophilia,
pubmed-meshheading:8335848-Humans,
pubmed-meshheading:8335848-Immunoglobulin E,
pubmed-meshheading:8335848-In Situ Hybridization,
pubmed-meshheading:8335848-Lymph Nodes,
pubmed-meshheading:8335848-Male,
pubmed-meshheading:8335848-Middle Aged,
pubmed-meshheading:8335848-Nucleic Acid Hybridization,
pubmed-meshheading:8335848-Oligonucleotide Probes,
pubmed-meshheading:8335848-Phenotype,
pubmed-meshheading:8335848-Polymerase Chain Reaction,
pubmed-meshheading:8335848-Sezary Syndrome,
pubmed-meshheading:8335848-T-Lymphocytes
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Sézary syndrome with elevated serum IgE and hypereosinophilia: role of dysregulated cytokine production.
|
| pubmed:affiliation |
Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, University of Colorado Health Sciences Center, Denver 80206.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|