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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1993-8-25
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pubmed:abstractText |
Rhodococcus globerulus P6 (previously designated Acinetobacter sp. strain P6, Arthrobacter sp. strain M5, and Corynebacterium sp. strain MB1) is able to degrade a wide range of polychlorinated biphenyl (PCB) congeners. The genetic and biochemical analyses of the PCB catabolic pathway reported here have revealed the existence of a PCB gene cluster--bphBC1D--and two further bphC genes--bphC2 and bphC3--that encode three narrow-substrate-specificity enzymes (2,3-dihydroxybiphenyl dioxygenases) that meta cleave the first aromatic ring. None of the bphC genes show by hybridization homology to each other or to bphC genes in other bacteria, and the three bphC gene products have different kinetic parameters and sensitivities to inactivation by 3-chlorocatechol. This suggests that there exists a wide diversity in PCB meta cleavage enzymes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-1318499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-1444254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-1575472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-1610186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-16346490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-1955878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-2050635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-2172216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-2216726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-2311936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-2356133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-2493454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-2493455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-2507526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-2729981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3009395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3041370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3063207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3085588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3100508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3111365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3137968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3140725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3140775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-3533101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-377280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-4008443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-4325686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-6343352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-6345791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-6412627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-673133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-6814360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-6950388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-806964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335622-8428946
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
175
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pubmed:geneSymbol |
bphC
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4631-40
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:8335622-Chromosome Mapping,
pubmed-meshheading:8335622-Chromosomes, Bacterial,
pubmed-meshheading:8335622-Cloning, Molecular,
pubmed-meshheading:8335622-Dioxygenases,
pubmed-meshheading:8335622-Genes, Bacterial,
pubmed-meshheading:8335622-Kinetics,
pubmed-meshheading:8335622-Multigene Family,
pubmed-meshheading:8335622-Oxygenases,
pubmed-meshheading:8335622-Polychlorinated Biphenyls,
pubmed-meshheading:8335622-Recombination, Genetic,
pubmed-meshheading:8335622-Rhodococcus,
pubmed-meshheading:8335622-Sequence Homology
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pubmed:year |
1993
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pubmed:articleTitle |
Three different 2,3-dihydroxybiphenyl-1,2-dioxygenase genes in the gram-positive polychlorobiphenyl-degrading bacterium Rhodococcus globerulus P6.
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pubmed:affiliation |
Department of Microbiology, National Research Center for Biotechnology, Braunschweig, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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