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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1993-8-26
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pubmed:databankReference |
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pubmed:abstractText |
Streptococcus suis type 2 strains that are pathogenic for pigs produce a 110-kDa extracellular protein factor (EF). Nonpathogenic and weakly pathogenic strains do not produce EF or produce a protein (EF*) that is immunologically related to EF. To study the pathogenesis of S. suis type 2 in pigs and to develop tools and methods for the control of S. suis type 2 infections, we cloned and characterized the genes encoding EF and various EF* proteins. Analysis of the deduced amino acid sequences showed that the first 833 amino acids at the N terminus of the EF and EF* proteins were nearly identical. The proteins differed, however, at their C termini. Unlike the 110-kDa EF protein, the EF* proteins contained several repeated units of 76 amino acids. The number and arrangement of the repeats in the EF* proteins varied. The data suggest that the gene encoding EF could have evolved from an epf* gene by a specific deletion event. The lack of repeated amino acid units in the EF protein may be related to virulence.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-1587602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-1730489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-1830357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-1879937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-1903505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-2046545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-2161989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-2460864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-2521391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-2774320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-3039291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-3138528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-319344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-3323801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-3353625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-3511046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-3527045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-3714490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-3745123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-4071952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-4519026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-5432063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-6269063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335363-6839111
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:geneSymbol |
epf,
epf*
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3318-26
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8335363-Amino Acid Sequence,
pubmed-meshheading:8335363-Bacterial Proteins,
pubmed-meshheading:8335363-Base Sequence,
pubmed-meshheading:8335363-Cloning, Molecular,
pubmed-meshheading:8335363-Genes, Bacterial,
pubmed-meshheading:8335363-Molecular Sequence Data,
pubmed-meshheading:8335363-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:8335363-Sequence Homology, Nucleic Acid,
pubmed-meshheading:8335363-Streptococcus suis
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pubmed:year |
1993
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pubmed:articleTitle |
Repeats in an extracellular protein of weakly pathogenic strains of Streptococcus suis type 2 are absent in pathogenic strains.
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pubmed:affiliation |
Department of Molecular Biology, DLO-Central Veterinary Institute, Lelystad, The Netherlands.
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pubmed:publicationType |
Journal Article
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