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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1993-8-26
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pubmed:abstractText |
To determine the potential for differential release of islet amyloid polypeptide and insulin, we performed studies in rat islet monolayer cultures under conditions known to impair regulated beta-cell secretion. In inhibiting concentrations of epinephrine or the absence of calcium, islet amyloid polypeptide was secreted through a constitutive pathway while insulin was not. These findings suggest a mechanism for persistent islet amyloid polypeptide secretion and amyloid accumulation when regulated insulin release is impaired as in Type 2 (non-insulin-dependent) diabetes mellitus and insulinomas.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0012-186X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
570-3
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:8335181-Amyloid,
pubmed-meshheading:8335181-Animals,
pubmed-meshheading:8335181-Animals, Newborn,
pubmed-meshheading:8335181-Calcium,
pubmed-meshheading:8335181-Cells, Cultured,
pubmed-meshheading:8335181-Epinephrine,
pubmed-meshheading:8335181-Glucose,
pubmed-meshheading:8335181-Insulin,
pubmed-meshheading:8335181-Islet Amyloid Polypeptide,
pubmed-meshheading:8335181-Islets of Langerhans,
pubmed-meshheading:8335181-Kinetics,
pubmed-meshheading:8335181-Rats,
pubmed-meshheading:8335181-Rats, Sprague-Dawley
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pubmed:year |
1993
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pubmed:articleTitle |
Evidence for selective release of rodent islet amyloid polypeptide through the constitutive secretory pathway.
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pubmed:affiliation |
Department of Medicine, University of Washington, Seattle.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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