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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1993-8-26
|
| pubmed:abstractText |
There is evidence that the immune system may play a role in the pathogenesis of autonomic neuropathy in Type 1 (insulin-dependent) diabetes mellitus. In the present study, we investigated the presence of autoantibodies to sympathetic and parasympathetic nervous structures and their correlation with other conventional autoantibodies in well-characterised diabetic populations, with or without diabetic neuropathy, and normal subjects. An indirect immunofluorescent complement-fixation technique was used, with monkey adrenal gland, rabbit cervical ganglia and vagus nerve as substrates. Of the patients with symptomatic autonomic neuropathy 33% were positive for at least one autoantibody (20% anti-sympathetic ganglia, 10% anti-vagus nerve and 13% anti-adrenal medulla). The frequency of having one or more antibodies to nervous tissues and the prevalence of anti-cervical ganglia antibodies were significantly higher in the neuropathic patients than in the diabetic control subjects with disease of similar duration and in the normal subjects (p < 0.05). Of the patients without complications with diabetes of shorter duration 33% were also positive for at least one autoantibody (13% anti-ganglia, 13% anti-vagus nerve and 13% anti-adrenal medulla). No correlation was found with other tissue autoantibodies, including islet cell antibodies. Our data indicate that nervous tissue autoantibodies are associated with symptomatic autonomic neuropathy. Anti-sympathetic ganglia and anti-vagus nerve antibodies seem to be more disease-specific. Patients with diabetes of shorter duration who were positive for these autoantibodies may represent pre-neuropathic patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0012-186X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
564-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8335180-Adolescent,
pubmed-meshheading:8335180-Adrenal Glands,
pubmed-meshheading:8335180-Adult,
pubmed-meshheading:8335180-Animals,
pubmed-meshheading:8335180-Autoantibodies,
pubmed-meshheading:8335180-Autonomic Nervous System,
pubmed-meshheading:8335180-Blood Pressure,
pubmed-meshheading:8335180-Child,
pubmed-meshheading:8335180-Child, Preschool,
pubmed-meshheading:8335180-Diabetes Mellitus, Type 1,
pubmed-meshheading:8335180-Diabetic Neuropathies,
pubmed-meshheading:8335180-Female,
pubmed-meshheading:8335180-Fluorescent Antibody Technique,
pubmed-meshheading:8335180-Ganglia, Sympathetic,
pubmed-meshheading:8335180-Haplorhini,
pubmed-meshheading:8335180-Heart Rate,
pubmed-meshheading:8335180-Humans,
pubmed-meshheading:8335180-Male,
pubmed-meshheading:8335180-Middle Aged,
pubmed-meshheading:8335180-Nerve Fibers,
pubmed-meshheading:8335180-Rabbits,
pubmed-meshheading:8335180-Reference Values,
pubmed-meshheading:8335180-Time Factors,
pubmed-meshheading:8335180-Vagus Nerve,
pubmed-meshheading:8335180-Valsalva Maneuver
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Autoantibodies to nervous tissue structures are associated with autonomic neuropathy in type 1 (insulin-dependent) diabetes mellitus.
|
| pubmed:affiliation |
Diabetic Department, King's College Hospital, London, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|