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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
3
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pubmed:dateCreated |
1993-8-26
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pubmed:abstractText |
The affinities of antagonists at histamine H1 receptors on HeLa cells have been determined from inhibition of histamine-induced inositol phosphate formation in intact and from inhibition of [3H]mepyramine binding to HeLa cell membranes. The dissociation constants of mepyramine and (+)-chlorpheniramine were similar to values for binding to H1 receptors in other mammalian tissues, but much lower than the values reported in an earlier study with [3H]mepyramine and HeLa cell membranes. Evidence is presented that under conditions employed in the earlier study the binding of [3H]mepyramine is largely to secondary, non-H1 receptor sites.
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pubmed:grant |
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0014-2999
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
15
|
|
pubmed:volume |
245
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
291-5
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|
pubmed:dateRevised |
2010-8-25
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pubmed:meshHeading |
|
|
pubmed:year |
1993
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pubmed:articleTitle |
Characteristics of histamine H1 receptors on HeLa cells.
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|
pubmed:affiliation |
Department of Pharmacology, University of Cambridge, UK.
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|
pubmed:publicationType |
Journal Article
|
