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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1993-8-20
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pubmed:databankReference |
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pubmed:abstractText |
We report that the third intron of the L1 ribosomal protein gene of Xenopus laevis encodes a previously uncharacterized small nucleolar RNA that we called U16. This snRNA is not independently transcribed; instead it originates by processing of the pre-mRNA in which it is contained. Its sequence, localization and biosynthesis are phylogenetically conserved: in the corresponding intron of the human L1 ribosomal protein gene a highly homologous region is found which can be released from the pre-mRNA by a mechanism similar to that described for the amphibian U16 RNA. The presence of a snoRNA inside an intron of the L1 ribosomal protein gene and the phylogenetic conservation of this gene arrangement suggest an important regulatory/functional link between these two components.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-1282084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-1408749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-1545793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-1550574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-1563354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-1730739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-1837522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2156625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2251119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2357971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2448138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2531075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2531660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2686980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2790958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2933102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-2959855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-3357768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-3399384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-3841512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-4109871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-500626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-6112733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-6180681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-6203742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8335006-6311685
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Ribonucleoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/fibrillarin,
http://linkedlifedata.com/resource/pubmed/chemical/ribosomal protein L1
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:geneSymbol |
L1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2921-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8335006-Animals,
pubmed-meshheading:8335006-Base Sequence,
pubmed-meshheading:8335006-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:8335006-Conserved Sequence,
pubmed-meshheading:8335006-DNA,
pubmed-meshheading:8335006-Humans,
pubmed-meshheading:8335006-Introns,
pubmed-meshheading:8335006-Molecular Sequence Data,
pubmed-meshheading:8335006-Nucleic Acid Hybridization,
pubmed-meshheading:8335006-RNA, Messenger,
pubmed-meshheading:8335006-RNA, Small Nuclear,
pubmed-meshheading:8335006-RNA Precursors,
pubmed-meshheading:8335006-RNA Processing, Post-Transcriptional,
pubmed-meshheading:8335006-Ribonucleoproteins,
pubmed-meshheading:8335006-Ribosomal Proteins,
pubmed-meshheading:8335006-Transcription, Genetic,
pubmed-meshheading:8335006-Xenopus laevis
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pubmed:year |
1993
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pubmed:articleTitle |
A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA.
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pubmed:affiliation |
Centro Acidi Nucleici of CNR, Università La Sapienza, Roma, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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