| pubmed-article:8334682 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8334682 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8334682 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:8334682 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:8334682 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8334682 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:8334682 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:8334682 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:8334682 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:8334682 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8334682 | pubmed:dateCreated | 1993-8-24 | lld:pubmed |
| pubmed-article:8334682 | pubmed:abstractText | The purpose of this study was to examine the mechanisms by which liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) stimulates monocytes to produce tumor necrosis factor (TNF) and interleukin-1 (IL-1). We have previously shown that secretion of TNF protein occurred 2-4 h following incubation of monocytes with L-MTP-PE and that this stimulation of TNF production was associated with an increase in TNF mRNA. Increased intracellular interleukin-1 alpha (IL-1 alpha) and IL-1 beta were not detected until 8 h after exposure to L-MTP-PE. To determine whether TNF played a role in the stimulation of IL-1 production by L-MTP-PE, normal human monocytes were incubated with L-MTP-PE or medium in the presence or absence of anti-TNF or anti IL-1 alpha plus anti IL-1 beta. Enhanced expression of IL-1 alpha and IL-1 beta mRNA was inhibited at 4 h but not 24 h when monocytes were incubated with L-MTP-PE plus anti-TNF compared with L-MTP-PE alone. By contrast, enhanced expression of TNF mRNA was not inhibited at any time when monocytes were incubated with L-MTP-PE and anti-IL-1 alpha plus anti-IL-1 beta. These data indicate that the up-regulation of IL-1 seen in monocytes following L-MTP-PE exposure may be due in part to the production of TNF. The up-regulation of TNF, however, appears to be independent of IL-1 production. | lld:pubmed |
| pubmed-article:8334682 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8334682 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8334682 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8334682 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:8334682 | pubmed:issn | 0340-7004 | lld:pubmed |
| pubmed-article:8334682 | pubmed:author | pubmed-author:AsanoTT | lld:pubmed |
| pubmed-article:8334682 | pubmed:author | pubmed-author:MaedaMM | lld:pubmed |
| pubmed-article:8334682 | pubmed:author | pubmed-author:KleinermanE... | lld:pubmed |
| pubmed-article:8334682 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8334682 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:8334682 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8334682 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8334682 | pubmed:pagination | 203-8 | lld:pubmed |
| pubmed-article:8334682 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:meshHeading | pubmed-meshheading:8334682-... | lld:pubmed |
| pubmed-article:8334682 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8334682 | pubmed:articleTitle | Anti-(tumor necrosis factor) alters the response of human monocytes to liposomal muramyl tripeptide. | lld:pubmed |
| pubmed-article:8334682 | pubmed:affiliation | Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030. | lld:pubmed |
| pubmed-article:8334682 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8334682 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:8334682 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
